FACTORS ASSOCIATED WITH FREQUENT BUPRENORPHINE / NALOXONE INITIATION IN A NATIONAL SURVEY OF CANADIAN EMERGENCY PHYSICIANS.

Factors associated with frequent buprenorphine / naloxone initiation in a national survey of Canadian emergency physicians.

ObjectiveTo identify individual and site-related factors associated with frequent emergency department (ED) buprenorphine/naloxone (BUP) initiation.BUP initiation, an effective opioid use disorder (OUD) intervention, varies widely across Canadian EDs.MethodsWe surveyed emergency physicians in 6 Canadian provinces from 2018 to 2019 using bilingual p

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Improvement of Antitumor Therapies Based on Vaccines and Immune-Checkpoint Inhibitors by Counteracting Tumor-Immunostimulation

Immune-checkpoint inhibitors and antitumor vaccines may DOLLS produce both tumor-inhibitory and tumor-stimulatory effects on growing tumors depending on the stage of tumor growth at which treatment is initiated.These paradoxical results are not necessarily incompatible with current tumor immunology but they might better be explained assuming the in

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